I had not thought about separate profiles until now. So I started thinking.
Take these thoughts as purely applying to the monitor that I am using.
The monitor has a "mode" button which switches between presets and those presets are -- text, picture, movie, srgb and custom. There are very visible differences between the modes particularly in brightness, contrast and tones. Several of the presets such as srgb do not allow you to alter the white balance setting and although the colours look ok compared to the "picture" mode that I use as the base for editing which is also the mode used when calibrating, the contrast and detail look "flat" when viewing in srgb mode.
I feel that once the monitor is set by the calibration software, altering the screen presets will simply give you a different set of tone curves to begin with.
I don't understand all the science behind monitors and calibrating so hearing what the Eizo rep has to say about it all will be enlightening.