I'll pick my best and worst lenses out of my 50mm lens collection...I own 178 50mm lenses for 35mm cameras...
Best 50mm : Leica Noctilux 50mm f0.95 ASPH - a step up in resolution from the classic noctilux 50mm f/1.0, coma and spherical aberrations have been substantially improved upon and the extra speed is welcome. The design of the lens hood could be improved a bit. Though from a bokeh point of view this lens can produce results that will bring a tear from your eye and on some occasions make you want to stick a fork in your eye.
this is actually really difficult for me to single out any particular 50mm lens that I consider worse than others, every lens manufacturer occasionally comes out with some really shocking 50mm lenses. They tend to be really old, non macro lenses and Feature apertures of f/2 or slower, to simplify things I think I'll use a current example.
Worst 50mm : Canon 50mm f/1.8 - I know, this lenses performance is almost indistinguishable from the f/1.2 and f/1.4 canon lenses at apertures of f/4 and smaller (bokeh tends to give it away though). However, the construction quality of this lens just screams out "bottom of the barrel" to me, and the plastic lens mount...nice touch canon.